Nexus of Rare Neurodegenerative Diseases

Group of courageous scientists and clinician

Multi-disciplinary research network

Serving patients with rare disease

Developing novel treatment strategies and drug

Nexus of Rare Neurodegenerative Diseases (NRND) is a multi-disciplinary research network. NRND gathers a group of courageous scientists and clinicians with collegial and creative mindsets. We are devoted to unveiling novel genetic causes of rare neurodegenerative and neuromuscular diseases, to understand the pathogenesis of these rare disorders, as well as developing novel treatment strategies for these diseases. We provide up-to-date R&D information of rare neurodegenerative & neuromuscular diseases to patient support groups in the Asia-Pacific region.

Research Topics

Identification of novel gene mutations that cause rare neurodegenerative and neuromuscular diseases

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Identification of novel gene mutations that cause rare neurodegenerative and neuromuscular diseases

After more than 4 years of research, Professor Edwin Chan and his colleagues identified a novel genetic mutation that leads to spinocerebellar ataxia (SCA). By means of next generation sequencing, the team first tracked down candidate disease-causing polymorphisms in the patients’ genomes. With concerted experimental and bioinformatic effort, the researchers finally confined the SCA mutation …

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Pathogenic mechanism studies of rare neurodegenerative and neuromuscular diseases

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Pathogenic mechanism studies of rare neurodegenerative and neuromuscular diseases

Having dedicated years of work into pathogenic mechanisms, Professor Chan and his team have made remarkable progress in understanding the underlying causes of rare diseases. These new discoveries have made great contributions to biomedical sciences. One case in point is the discovery of the role of Fuz protein in polyglutamine (polyQ) diseases, such as SCA and …

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Drug development for rare neurodegenerative and neuromuscular diseases

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Drug development for rare neurodegenerative and neuromuscular diseases

The first step to the lengthy process of developing a new drug is the discovery of drug candidate – a compound that shows therapeutic potentials. The study of pathogenic mechanism of rare diseases at NRND have led to some major breakthroughs in understanding polyQ diseases, presenting great potential for developing drugs to restrain and treat …

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Every contribution, no matter big or small, will directly impact the discovery and development of therapeutics for rare diseases – pathing the way to more break-throughs and saved lives.