Laboratory of Drosophila Research

[ back ]

Publication List:

* denotes corresponding author

123) Žakelj, N., Gosar, D., Miroševič, S., Sanders, S.J., Ljungdhal, A., Kohani, S., Huang, S., Leong, L.I, An, Y., Teo, M., Moultrie, F., Jerala, R., Lainšček, D., Forstnerič, V., Sušjan, P., Lisowski, L., Perez-Iturralde, A., Mark, J.O., Chan, H.Y.E. and Osredkar, D. (2025) Genotypic, functional, and phenotypic characterization in CTNNB1 neurodevelopmental syndrome. HGG Advances 6, 100483. doi: 10.1016/j.xhgg.2025.100483.[ abstract ]

122) Chen, Z.S., Peng, S.I., Leong, L.I, Gall-Duncan, T., Wong, N.S.J., Li, T.H., Lin, X., Wei, Y., Koon, A.C., Huang, J., Sun, J.K., Turner, C., Tippett, L., Curtis, M.A., Faull, R.L.M., Kwan, K.M., Chow, H.M., Ko, H., Chan, T.F., Pearson, C.E. and Chan, H.Y.E.* (2025) Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5. Nat. Commun. 16(1):3307[ abstract ]

121) Liang Z., Murugappan, S.K., Li, Y., Lai, M.N., Chan, H.Y.E., Lee, M.M. and Chan, M.K.* (2025) Gene delivery of SUMO1-derived peptide rescues neuronal degeneration and motor deficits in rAAV-α-syn-A53T Parkinson’s Disease mouse model. Mol. Ther. S1525-0016(25)00279-5[ abstract ]

120) Ngai, C.S.B., Singh, R.G., Huang, Y., Ho, J.W.Y., Khong, M.L., Chan, E., Lau, T.C.K., Chan, H.Y.E., Wong, W.T., Law, M.S.M. and Koon, A.C.* (2025) Development of a systematic humor pedagogical framework to enhance student learning outcomes across different disciplines in Hong Kong. Int. J. Educ. Res. Open 8, 100438[ abstract ]

119) Li, J., Leung, S.S.Y., Chan, H.Y.E., Jiang, C., Ho, E.T.Y. and Zuo, Z.* (2025) Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement. Int. J. Nanomedicine 20, 3945-3959[ abstract ]

118) Chau, D.D., Yu, Z., Chan, W.W.R., Zhai, Y., Chang, R.C.C., Ngo, J.C.K., Chan, H.Y.E. and Lau, K.F. (2024) The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing. Cell Mol. Life Sci. 81(1):323[ abstract ]

117) Chen, F.M., Li, H., Chung D.L., Mak, A.T.L., Leung, F.P., Chan, H.Y.E. and Wong, W.T. (2024) IL-4/STAT6 axis observed to reverse proliferative defect in SCA3 patient-derived neural progenitor cells. Clin. Exp. Pharmacol. Physiol. 51(1): 30-39[ abstract ]

116) Chen, Z.S., Ou, M., Taylor, S., Dafinca, R., Peng, S.I., Talbot, K.* and Chan, H.Y.E.* (2023) Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulate Wnt/b-catenin pathway in C9ALS/FTD. Nat. Commun. 14(1):8420[ abstract ]

115) Santorelli, F.M., McLoughlin, H.S., Wolter, J.M., Galatolo, D., Synofzik, M., Mengel, D., Opal, P. and AGI-WG2-Biomarkers Study Group (2023) Standards of Fluid Biomarker Collection and Pre-analytical Processes in Humans and Mice: Recommendations by the Ataxia Global Initiative Working Group on Biomarkers. Cerebellum doi: 10.1007/s12311-023-01561-1 (H.Y.E. CHAN is a member of the AG-WG2-Biomarkers Study Group)[ abstract ]

114) Klockgether, T., Synofzik, M. and AGI working group on COAs and Registries (2023) Consensus Recommendations for Clinical Outcome Assessments and Registry Development in Ataxias: Ataxia Global Initiative (AGI) Working Group Expert Guidance. Cerebellum doi: 10.1007/s12311-023-01547-z (H.Y.E. CHAN is a member of the AGI Working Group on COAs and Registries)[ abstract ]

113) Beijer, D., Fogel, B.L., Beltran, S., Danzi, M.C., Németh, A.H., Züchner, S., Synofzik, M. and AGI Ataxia NGS Genomics, platforms Working Group (2023) Standards of NGS data sharing and analysis in Ataxias: Recommendations by the NGS Working Group of the Ataxia Global Initiative. Cerebellum DOI: 10.1007/s12311-023-01537-1 (H.Y.E. CHAN is a member of the AGI Working Group on next-generation genomics and platforms) [ abstract ]

112) Sun, J.K., Wu, D., Wong, G.C., Lau, T.M., Yang, M., Hart, R.P., Kwan, K.M., Chan, H.Y.E. and Chow, H.M. (2023) Chronic alcohol metabolism results in DNA repair infidelity and cell cycle-induced senescence in neurons. Aging Cell 23:e13772[ abstract ]

111) Lau, M.H.Y., Wong, C.H., Chan, H.Y.E. and Au-Yeung, H.Y. (2022) Development of fluorescent turn-on probes for CAG-RNA repeats. Biosensors 12, 1080.[ abstract ]

110) Chen, Z.S., Yan, M., Pei, W., Yan, B., Huang, C.* and Chan, H.Y.E.* (2022) Lignin-carbohydrate complexes suppress SCA3 neurodegeneation via upregulating proteasomal activities. Int. J. Biol. Maromol. 218, 690-705.[ abstract ]

109) Chan, H.Y.E. and Chen, Z.S. (2022) Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma. Aging 14(19), 7794-7823.[ abstract ]

108) An, Y., Chen, Z.S., Chan, H.Y.E.* and Ngo, J.C.K.* (2022) Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases. Nucl. Acids Res. 50(13), 7655-7668 [ abstract ]

107) Peng, S.I., Leong, L.I., Sun, J.K., Chen, Z.S., Chow, H.M. and Chan, H.Y.E.* (2022) A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities. Mol. Ther. Nucleic Acids 29, 102-115.[ abstract ]

106) Yi, J., Wan, L., Liu Y., Lam, S.L., Chan, H.Y.E.*, Han, D.* and Guo, P.* (2022) NMR solution structures of d(GGCCTG)n repeats associated with spinocerebellar ataxia type 36. Int. J. Biol. Macromol. 201, 607-615[ abstract ]

105) Li, P.P., Moulick, R., Feng, H., Sun, X., Arbez, N., Jin, J., Marque, L.O., Hedglen, E., Chan, H.Y.E., Ross, C.A., Pulst, S.M., Margolis, R.L., Woodson, S. and Rudnicki, D.D. (2021) RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2. Mov. Disord. 36(11), 2519-2529[ abstract ]

104) Peng, S., Guo, P., Lin, X., An, Y., Sze, K.H., Lau, M.H.Y., Chen, Z.S., Wang, Q., Li, W., Sun, J.K., Ma, S.Y., Chan, T.F., Lau, K.F., Ngo, J.C.K., Kwan, K.M., Wong, C.H., Lam, S.L., Zimmerman, S.C., Tuccinardi, T., Zuo, Z., Au Yeung, H.Y., Chow, H.M. and Chan, H.Y.E.* (2021) CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration. Proc. Natl. Acad. Sci. USA. 118(19) e2022940118[ abstract ]

103) Chen, Z.S., Lin, X., Chan, T.F. and Chan, H.Y.E.* (2021) Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis. Aging 13(5) 7259-7283.[ abstract ]

102) Klionsky, D.J. ... Chan, H.Y.E. ...Tong, C.K. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1), 1-382.[ abstract ]

101) Yahia, A., Chen, Z.S., Ahmed, A.E., Emad, S., Adil, R., Abubaker, R., Taha, S.O., Salih, M.A., Elsayed, L., Chan, H.Y.E. and Stevanin, G. (2021) A heterozygous mutation in the CCDC88C gene likely causes early-onset pure hereditary spastic paraplegia: a case report. BMC Neurol 21(1):78[ abstract ]

100) Chen, Z.F., Huang, X., Talbot, K. and Chan, H.Y.E.* (2021) A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Cell Death Dis. 12(2):136.[ abstract ]

99) Liang, Z., Chan, H.Y.E., Lee, M.M. and Chan, M.K. (2021) A SUMO1-derived peptide targeting SUMO-interacting motif inhibits alpha-synuclein aggregation. Cell Chem. Biol. 28, 180-190.[ abstract ]

98) Lee, L.K., Leong, L.I., Liu, Y., Luo, M., Chan, H.Y.E.* and Choi, C.H.J.* (2021) Preclinical nanomedicines for polyglutamine-based neurodegenerative diseases. Mol. Pharm. 18, 610-626.[ abstract ]

97) Pei, W., Chen, Z.S., Chan, H.Y.E., Zheng, L., Liang, C. and Huang, C. (2020) Isolation and identification of a novel anti-protein aggregation activity of lignin-carbohydrate complex from Chionanthus retusus leaves. Front. Bioeng. Biotechnol. 8:573991 [ abstract ]

96) Zhao, L., Li, Z., Vong, J.S.L., Chen, X., Lai, H.M., Yan, L.Y.C., Huang, J., Sy, S.K.H., Tian, X., Huang, Y., Chan, H.Y.E., So, H.C., Ng, W.L., Tang, Y., Lin, W.J., Mok, V.C.T. and Ko, H. (2020) Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. Nat. Comm. 11(1):4413 [ abstract ]

95) Zhou, P., Chan, B.K.C., Wan, Y.K., Yuen, C.T.L., Choi, G.C.G., Li, X., Cheung, L.W.T., Tan, K., Wong, K.H., H.Y.E. Chan and Wong, A.S.L.* (2020) Three-way combinatorial CRISPR screen for analysing interactions among druggable targets. Cell Rep. 32, 108020 [ abstract ]

94) Wang, Q., Ren, T., Zhao, J., Wong, C.H., Chan, H.Y.E. and Zuo, Z. (2020) Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations. J. Pharm. Biomed. Anal. 178:112946 [ abstract ]

93) Yu, A.C., Yim, A.K., Chan, A.Y., Yuen, L.Y.P., Au, W.C., Cheng, T.H.T., Lin, X., Li, J.W., Chan, L.W.L., Mok, V.C.T., Chan, T.F.* and Chan, H.Y.E.* (2019) A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases. Front Neurosci. 13:1324.[ abstract ]

92) Chau, D.D., Yung, K.W., Chan, W.W., An, Y., Hao, Y., Chan, H.Y.E., Ngo, J.C. and Lau, K.F. (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 33, 12019-12035. [ abstract ]

91) Lee, J., Bai, Y., Chembazhi, U.V., Peng, S., Yum, K., Luu, L.M., Hagler, L.D. Serrano, J.F., Chan, H.Y.E., Kalsotra, A. and Zimmerman, S.C. (2019) Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1. Proc. Natl. Acad. Sci. USA 116, 8709-8714. [ abstract ]

90) Chen, Z.S. and Chan, H.Y.E. (2019) Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain? Neural Regen. Res. 14, 1148-1151. [ abstract ]

89) Law, C. O.K., Huang, C., Pan, Q., Lee, J., Hao, Q., Chan, T.F., Lo, N.W., Ang, I.L., Koon, A., Ip, M., Chan, H.Y.E. and Lau, T.C.K. (2019) A small RNA transforming multidrug resistance Pseudomonas aeruginosa to drug-susceptibility. Mol. Ther. Nucleic Acids 16, 218-228. [ abstract ]

88) Zhang, Q., An, Y., Chen, Z.S., Koon, A.C., Lau, K.F., Ngo, J.C.* and Chan, H.Y.E.* (2019) A peptidylic inhibitor for neutralizing r(GGGGCC)exp-associated neurodegeneration in C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Mol. Ther. Nucleic Acids 16, 172-185. [ abstract ]

87) Kim, M.R., Feng, T., Zhang, Q., Chan, H.Y.E. and Chau, Y. (2019) Co-encapsulation and co-delivery of peptide drugs via polymeric nanoparticles. Polymers 11(2), 288 [ abstract ]

86) Chen, Z.S., Wong, A.K.Y., Cheng, T.C., Koon, A.C. and Chan, H.Y.E.* (2019) FipoQ/FBXO33, a Cullin-1 based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. J. Neurochem. 149, 781-798 (Featured on the cover of the issue)[ abstract ]

85) Hong, H., Koon, A.C., Chen, Z.S., Wei, Y., An, Y., Li, W., Lau, M.H.Y., Lau, K.F., Ngo, J.C.K., Wong, C.H., Au-Yeung, H.Y., Zimmerman, S.C., Chan, H.Y.E.* (2019) AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. J. Biol. Chem. 294, 2757-2770 (Featured on the cover of the issue) [ abstract ]

84) Lenska-Mieciek, M., Charzewska, A., Krolicki, L., Hoffman-Zacharska, D., Chen, Z.S., Lau, K.F., Chan, H.Y.E., Gambin, T. and Fiszer, U. (2019) Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene. Mov. Disord. 34, 142-144.[ abstract ]

83) Wang, Q., Peng, S., Hu, Y., Wong, C.H., Kwan, K.M., Chan, H.Y.E. and Zuo, Z. (2019) Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration. Eur. J. Pharm. Sci. 127, 240-251.[ abstract ]

82) Yang, M., Zhang, Q., Wang, Q., Sorensen, K.K., Boesen, J.T., Ma, S.Y., Jensen, K.J., Kwan, K.M., Ngo, J.C.K., Chan, H.Y.E. and Zuo, Z. (2018) Brain-targeting delivery of two peptidylic inhibitors for their combination therapy in transgenic polyglutamine disease mice via intranasal administration. Mol. Pharm. 15, 5781-5792. [ abstract ]

81) Koon, A.C., Chen, Z.S., Peng, S.H., Fung, J.M., Zhang, X., Lembke, K.M., Chow, H.K., Frank, C.A., Jiang, L.W., Lau, K.F. and Chan, H.Y.E.* (2018) Drosophila Exo70 is essential for neurite extension and survival under thermal stress. J. Neurosci. 38, 8071-8086.[ abstract ]

80) Chen, Z.S., Li, L., Peng, S., Chen, F.M., Zhang, Q., An, Y., Lin, X., Li, W., Chan, T.F., Lau, K.F., Ngo, J.C., Wong, W.T., Kwan, K.M. and Chan, H.Y.E.* (2018) Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative diseases. EMBO Rep. 19, e45419[ abstract ]

79) Tse, W.S., Siu, A.F.Y., Zhang, Q. and Chan, H.Y.E. (2018) Maternal oxytocin responsiveness improves specificity of positive social memory recall. Psychoneuroendocrinology 98, 148-152.[ abstract ]

78) Li, W., Tam, K.M., Chan, W.W., Koon, A.C., Ngo, J.C., Chan, H.Y.E. and Lau, K.F. (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J. Biol. Chem. 293, 7674-7688.[ abstract ]

77) Zhang, Q., Chan, Z.S., An, Y., Liu, H., Hou, Y., Li, W., Lau, K.F., Koon, A.C., Ngo, J.C.K.* and Chan, H.Y.E.* (2018) A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases. RNA 24, 486-498. [ abstract ]

76) Wang, Q., Wong, C.H., Chan, H.Y.E., Lee, W.Y. and Zuo, Z. (2018) Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery. Int. J. Pharm. 539, 50-57. [ abstract ]

75) Tse, W.S., Siu, A.F.Y., Zhang, Q., Chan, H.Y.E. and Wong, T.K.Y. (2017) How does maternal oxytocin influence children’s mental health problem and maternal health problem? Psychiatry Res. 258C, 124-129.[ abstract ]

74) Wang, Q., Zhang, Y., Wong, C.H., Chan, H.Y.E. and Zuo, Z. (2017) Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling. AAPS J. 2017 Dec 27;20(1):23. doi: 10.1208/s12248-017-0179-0 [ abstract ]

73) Qu, Z., Bendena, W.G., Nong, W., Siggens, K.W.,, Noriega, F.G., Kai, Z.P., Zang, Y.Y., Koon, A.C., Chan, H.Y.E., Chan, T.F., Chu, K.H., Lam, H.M., Akam, M., Tobe, S.S. and Hui, J.H. (2017) MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods. Proc Biol Sci. 2017 Dec 20;284(1869). pii: 20171827. doi: 10.1098/rspb.2017.1827. [ abstract ]

72) Zhang, Q., Yang, M., Sorensen, K.K., Madsen, C.S., Boesen, J.T., An, Y., Peng, S.H., Wei, Y., Wang, Q., Jensen, K.J., Zuo, Z., Chan, H.Y.E.* and Ngo, J.C.K.* (2017) A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in polyglutamine diseases. Sci. Rep. 7(1):12077. [ abstract ]

71) Guo, P., Chan, H.Y.E. and Lam, S.L. (2017) Conformational flexibility in the RNA stem-loop structures formed by CAG repeats. FEBS Lett. 591, 1752-1760.[ abstract ]

70) Koon, A.C. and Chan, H.Y.E.* (2017) Drosophila melanogaster as a model organism to study RNA toxicity of repeat expansion-associated neurodegenerative and neuromuscular diseases. Front. Cell. Neurosci. 11:70. doi: 10.3389/fncel.2017.00070 [ abstract ]

69) Li L., Ng, N.K. Koon, A.C., Chan, H.Y.E.* (2017) Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eukaryotic translation elongation factor 1 alpha 1. J. Biol. Chem. 292, 5784-5800. [ abstract ]

68) Yu, A.C., Chan, A.Y., Au, W.C., Shen, Y., Chan, T.F.* and Chan, H.Y.E.* (2016) Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11. Cold Spring Harb. Mol. Case Stud. 2(6):a001248 [ abstract ]

67) Bai, Y., Nyuyen, L., Song, Z., Peng, S.H., Zheng, N., Lee, J., Kapoor, I., Cheng, J., Chan, H.Y.E. and Zimmerman, S.C. (2016) Integrating display and delivery functionality with a cell penetrating peptide mimic as a scaffold for intracellular multivalent multi-targeting. J. Am. Chem. Soc. 138, 9498-9507 [ abstract ]

66) Yang, H., Chen, Z., Zhang, L. Yung, W.Y., Leung K.C., Chan, H.Y.E. and Choi, C.H.J.* (2016) Mechanism for the cellular uptake of targeted gold nanorods of defined aspect ratios. Small 12, 5178-5189 [ abstract ]

65) Luu, L.M., Nyuyen, L., Peng, S., Lee, J., Lee, H.Y., Wong, C.H., Hergenrother, P.J., Chan, H.Y.E.* and Zimmerman, S.C.* (2016) A potent inhibitor of protein sequestration by expanded triplet (CUG) repeats that shows phenotypic improvements in a Drosophila model of myotonic dystrophy. ChemMedChem 11, 1428-1435. [ abstract ]

64) Liao, Q, Chan, A,Y,Y,, Chan, H.Y.E., Mok, V.C.T., Baum, L. (2016) Haplotype analysis of association between Parkinsonˇ¦s disease and the embryonic lethal, abnormal vision-like 4 (ELAVL4) gene. J. Biochem. Mol. Biol. Post Genomic Era 3, 129-37. [ abstract ]

63) Ko, C.H., Koon, C.M., Yu, S.L., Lee, K.Y., Lau, C.B., Chan, E.H., Wing, Y.K., Fung, K.P. and Leung, P.C. (2016) Hypnotic effects of a novel anti-insomnia formula on drosophila insomnia model. Chin. J. Integr. Med. 22, 335-343. [ abstract ]

62) Wang, Q., Zhang, Y., Qian S., Peng, S., Zhang, Q., Wong, C.H., Chan, H.Y.E. and Zuo, Z. (2016) Pharmacokinetic and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats. J. Pharm. Biomed. Anal. 125, 41-47. [ abstract ]

61) Zhang, Q., Tsoi, H., Peng, S., Li, P.P., Lau, K.F., Rudnicki, D.D., Ngo, J.C. and Chan, H.Y.E.* (2016) Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila. Dis. Model. Mech. 9, 321-34 [ abstract ]

60) Nguyen, L., Luu, L.M., Peng, S., Serrano, J.F., Chan, H.Y.E. and Zimmerman, S.C. (2015) Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy Type 1. J. Am. Chem. Soc. 137, 14180-14189 [ abstract ]

59) Sun, X., Li, P.P., Zhu, S., Cohen, R., Marque, L.O., Ross, C.A., Pulst, S.M., Chan, H.Y.E., Margolis, R.L. and Rudnicki, D.D. (2015) Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65. Sci. Rep. 28;5:12521. [ abstract ]

58) Chow, W.N., Ngo, J.C., Li, W., Chen, Y.W., Tam, K.M., Chan H.Y.E., Miller, C.C. and Lau, K.F. (2015) Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing. Biochem. J. 470, 303-17. [ abstract ]

57) Tsoi H., Li, L., Chan, Z.S., Lau, K.F., Tsui, S.K. and Chan, H.Y.E.* (2014) The SARS-Coronavirus Membrane protein induces apoptosis via interfering PDK1-PKB/Akt signaling. Biochem. J. 464, 439-447.[ abstract ]

56) Chan, H.Y.E.* (2014) RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis. Front. Cell. Neurosci. 8:431. doi: 10.3389/fncel.2014.00431 [ abstract ]

55) Tsoi, H., Yu, A.C., Chen, Z.S., Ng, N.K., Chan, A.Y., Yuen, L.Y., Abrigo, J.M., Tsang, S.Y., Tsui, S.K., Tong, T.M., Lo, I.F., Lam, S.T., Mok, V.C, Wong, L.K., Ngo, C.K., Lau, K.F., Chan, T.F.* and Chan, H.Y.E.* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51, 590-595. [ abstract ]

54) Wong, C.H., Nguyen, L., Peh, J., Luu, L.M., Sanchez, J.S., Richardson, S.L., Tuccinardi, T., Tsoi, H., Chan, W.Y., Chan, H.Y.E., Baranger, A.M., Hergenrother, P.J. and Zimmerman, S.C. (2014) Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor. J. Am. Chem. Soc. 136, 6355-61.[ abstract ]

53) Tsoi, H. and Chan, H.Y.E.* (2014) Roles of the nucleolus in the CAG RNA-mediated toxicity. Biochim. Biophys. Acta. 1842, 779-784.[ abstract ]

52) Cheung, H.N., Dunbar, C., Morotz, G.M., Cheng, W.H., Chan, H.Y.E., Miller, C.C. and Lau, K.F. (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J. 28, 337-349. [ abstract ]

51) Zuo, Y., Peng, C., Liang, Y., Ma, K.Y., Chan, H.Y.E., Huang, Y. and Chen, Z.Y. (2013) Sesamin extends the mean lifespan of fruit flies. Biogerontology 14, 107-119.[ abstract ]

50) Tsoi, H. and Chan, H.Y.E.* (2013) Expression of expanded CAG transcripts triggers nucleolar stress in Huntingtonˇ¦s disease. Cerebellum 12, 310-312. [ abstract ]

49) Ng, C.F., Ko, C.H., Koon, C.M., Xian, J.W., Leung, P.C., Fung, K.P., Chan, H.Y.E. and Lau, C.B. (2013) The aqueous extract of rhizome of Gastrodia elata protected Drosophila and PC12 cells against beta-amyloid-induced neurotoxicity. Evid. Based Complement Alternat. Med. 2013:516741.[ abstract ]

48) Tsoi, H., Lau, C.K., Tsang, S.Y., Lau, K.F. and Chan, H.Y.E.* (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc. Natl. Acad. Sci. USA.109, 13428-13433. [ abstract ]

47) Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.* and Li, M.* (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8, 98-108.[ abstract ]

46) Peng, C., Zuo, Y., Kwan, K.M., Liang, Y., Ma, K.Y., Chan, H.Y.E., Huang, Y., Yu, H. and Chen, Z.Y. (2012) Blueberry extract prolongs lifespan of Drosophila melanogaster. Exp. Gerontol. 47, 170-178.[ abstract ]

45) Hao, Y., Chai, K.H., McLoughlin, D.M., Chan, H.Y.E. and Lau, K.F. (2012) Promoter characterization and genomic organization of the human X11Ł] gene APBA2. Neuroreport 23, 146-151.[ abstract ]

44) Chai, K.H., McLoughlin, D.M., Chan, T.F., Chan, H.Y.E. and Lau, K.F. (2012) Genomic organization and promoter cloning of the human X11a gene APBA1. DNA Cell Biol. 31, 651-659.[ abstract ]

43) Chow, W.N., Luk, H.W., Chan, H.Y.E. and Lau, K.F. (2012) Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65. Biochem. J. 443, 681-689.[ abstract ]

42) Tsoi, H., Lau, T.C.K., Lau, K.F. and Chan, H.Y.E.* (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Hum. Mol. Genet. 20, 3787-3797.[ abstract ]

41) Chan, W.M., Tsoi, H., Wu, C.C., Wong, C.H., Cheng, T.C., Li, H.Y., Lau, K.F., Shaw, P.C., Perrimon, N. and Chan, H.Y.E.* (2011) Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Hum. Mol. Genet. 20, 1738-1750.[ abstract ]

40) Hao, Y., Perkinton, M.S., Chan, W.W., Chan, H.Y.E., Miller, C.C. and Lau, K.F. (2011) GULP1 is a novel APP-interacting protein that alters APP processing. Biochem. J. 436, 631-639.[ abstract ]

39) Peng, C., Chan, H.Y.E., Huang, Y., Yu, H. and Chen, Z.Y. (2011) Apple polyphenols extend lifespan of Drosophila melanogaster. J. Agri. Food Chem. 59, 2097-2106.[ abstract ]

38) Cheng, T.C., Chen, Y.W., Wong, K.B., Ngai, S.M. and Chan, H.Y.E.* (2010) Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis. Acta. Cryst. F 66, 546-548.[ abstract ]

37) Lee, F.K.M., Wong, A.K.Y., Lee, Y.W., Wan, O.W., Chan, H.Y.E.*, and Chung, K.K.K.* (2009) The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson s disease. J. Neurochem. 110, 208-219.[ abstract ]

36) Peng, C., Chan, H.Y.E., Li, Y.M., Huang, Y. and Chen, Z.Y. (2009) Black tea theaflavins extend the lifespan of fruit flies. Exp. Gerontol. 44, 773-783.[ abstract ]

35) Lam, S.K., Cai, Y., Tse, Y.C., Wang, J., Law, A.H.Y., Pimpl, P., Chan, H.Y.E., Xia, J., and Jiang, L.W. (2009) The BFA-induced compartments from Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. Plant J. 60, 865-881.[ abstract ]

34) Chan, C.M., Tsoi, H., Chan, W.M., Zhai, S., Wong, C.O., Yao, X., Chan, W.Y., Tsui, S.K.W., and Chan, H.Y.E.* (2009) The ion channel activity of the SARS-Coronavirus 3a protein is linked to its pro-apoptotic function. Int. J. Biochem. & Cell Biol. 41, 2232-2239[ abstract ]

33) Lau, K.F., Chan, W.M., Perkinton, M.S., Chang, R.C.C., Chan, H.Y.E., McLoughlin, D.M., and Miller, C.C.J. (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. J. Biol. Chem. 283, 34728-34737. [ abstract ]

32) Mugat, B., Parmentier, M.L., Bonneaud, N., Chan, H.Y.E., and Maschat, F. (2008) Protective role of Engrailed in a Drosophila model of Huntington"s disease. Hum. Mol. Genet. 17, 3601-3616. [ abstract ]

31) Lam, W., Chan, W.M., Lo, T.W., Wong, A.K.Y., Wu, C.C. and Chan, H.Y.E.* (2008) Human receptor for activated protein kinase C1 associates with polyglutamine aggregates and modulates polyglutamine toxicity. Biochem. Biophys. Res. Comm. 377, 714-719. [ abstract ]

30) Wong, J.H., Chan, H.Y.E. and Ng, T.B. (2008) A mannose/glucose-specific lectin from Chinese evergreen chinkapin (Castanopsis chinensis). Biochimica et Biophysica Acta. 1780, 1017-1022.[ abstract ]

29) Wong, A.K.Y., Chan, H.Y.E.* and Chan, W.M. (2008) Recent developments in targeted transgene expression systems. Fly 2, 169-171.[ abstract ]

28) Chen, F., Chan, H.Y.E., Wong, K.L., Wang, J., Yu, M.T., But, P.P. and Shaw, P.C. (2008) Authentication of Saussurea lappa, an Endangered Medicinal Material, by ITS DNA and 5S rRNA Sequencing. Planta Medica 74, 889-892.[ abstract ]

27) Li, Y.M., Chan, H.Y.E., Huang, Y. and Chen, Z.Y. (2008) Broccoli improves the survival and up-regulates endogenous antioxidant enzymes in Drosophila melanogaster challenged with reactive oxygen species. Journal of the Science of Food and Agriculture. 88, 499-506. [ abstract ]

26) Li, Y.M., Chan, H.Y.E., Yao, X.Q., Huang, Y. and Chen, Z.Y. (2008) Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster. Journal of Nutritional Biochemistry.19, 376-383. [ abstract ]

25) Wong, S.L.A., Chan, W.M. and Chan, H.Y.E.* (2008) SDS-insoluble polyglutamine oligomers are involved in neuronal degeneration. FASEB J. 22, 3348-3357. [ abstract ]

24) Chan, W.M., Shaw, P.C. and Chan, H.Y.E.* (2007) A green fluorescent protein-based reporter for protein import studies in Drosophila cells. Fly 1, 340-342. [ abstract ]

23) Li, Y.M., Chan, H.Y.E., Huang, Y. and Chen Z.Y. (2007) Green Tea Catechins Up-Regulate Superoxide Dismutase and Catalase in Fruit Flies. Mol. Nutr. & Food Res. 51, 546-554. [ abstract ]

22) Huen, N.Y.M., Wong, S.L.A. and Chan, H.Y.E.* (2007) Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias. The Cerebellum. (Invited review) 6, 111-117. [ abstract ]

21) Chan, C.M., Ma, C.W., Chan, W.Y. and Chan, H.Y.E.* (2007) The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway. Arch. Biochem. Biophys. 459, 197-207. (Featured on the cover of the issue) [ abstract ]

20) Chau, K.W., Chan, W.Y., Shaw, P.C., Chan, H.Y.E.* (2006) Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. Biochem Biophys Res Commun.346(1):150-9.[ abstract ]

19) Yiu, C.P.B., Beavil, R.L. and Chan, H.Y.E.* (2006) Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble. Biochem. Biophy. Res. Comm. 343, 311-318. [ abstract ]

18) Wong, S.L.A., Chen, Y.W., Chan, C.M. , Chan, C.S.M., Chan, P.K.S., Chui, Y.L., Fung, K.P., Waye, M.M.Y., Tsui, S.K.W. and Chan, H.Y.E.* (2005) In vivo functional characterization of the SARS Coronavirus 3a protein in Drosophila. Biochem. Biophy. Res. Comm. 337, 720-729. (Featured on the cover of the issue)[ abstract ]

17) Huen, N.Y.M. and Chan, H.Y.E.* (2005) Dynamic regulation of molecular chaperone gene expression in polyglutamine disease. Biochem. Biophy. Res. Comm. 334, 1074-1084.[ abstract ]

16) Law, P.T.W., Wong, C.H., Au, T.C.C., Chuck, C.P., Kong, S.K., Chan, P.K.S.,To, K.F., Lo, A.W.I., Chan, J.Y.W., Suen, Y.K., Chan, H.Y.E., Fung, K.P., Waye, M.M.Y., Sung, J.J.Y., Lo, Y.M.D., Tsui, S.K.W. (2005) The 3a protein of severe acute respiratory syndrome-coronavirus induces apoptosis in Vero E6 cells. J. Gen. Virol. 86, 1921-1930. [ abstract ]

15) Kusano, A., Staber, C., Chan, H.Y.E. and Ganetzky, B. (2003) Closing the (Ran)GAP on Segregation distortion in Drosophila. BioEssays 25, 108-115. (Featured on the cover of the issue)[ abstract ]

14) Chan, H.Y.E. and Bonini, N.M. (2003) Drosophila models of polyglutamine diseases. In: Methods in Molecular Biology; v. 217- Neurogenetics: Methods and protocols, (ed Potter N). Humana Press, Totowa, NJ, USA, pp. 241-251.[ abstract ]

13) Chan, H.Y.E.* (2002) Fly-ing from genes to drugs. Trends Mol. Med. 8(3), 99-101.[ abstract ]

12) Auluck, P.K., Chan, H.Y.E., Trojanowski, J.Q., Lee, V.M.Y. and Bonini, N.M. (2002) Chaperone suppression of a-synuclein toxicity in a Drosophila model for Parkinsons disease. Science 295, 865-868.10.1126/science.1067389[ abstract ]

11) Chan, H.Y.E.*, Tung, C.K.C. And Okane, C.J. (2002) Rev::GFP transgenic lines for the studies of nucleocytoplasmic transport in Drosophila. Genesis 34, 139-141.[ abstract ]

10) Chan, H.Y.E., Warrick, J.M., Andriola, I., Merry, D.E. and Bonini, N.M. (2002) Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Hum. Mol. Genet. 11, 2895-2904.[ abstract ]

9) Chan, H.Y.E., Brogna, S. and OKane, C.J. (2001) Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Mol. Biol. Cell 12, 1409-1419.[ abstract ]

8) Chan, H.Y.E., Warrick, J.M., Gray-Board, G.L., Paulson, H.L. and Bonini, N.M. (2000) Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy, and modulation of protein solubility in Drosophila. Hum. Mol. Genet. 9, 2811-2820. (Featured on the cover of the issue)[ abstract ]

7) Chan, H.Y.E. and Bonini, N.M. (2000) Drosophila models of human neurodegenerative disease. Cell Death and Differentiation 7, 1075-1080.[ abstract ]

6) Collier, S., Chan, H.Y.E., Toda, T., MacKimmie, C., Johnson, G., Adler, P., OKane, C. and Ashburner, M. (2000) The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of Schizosaccharomyces crm1. Genetics 155, 1799-1807.[ abstract ]

5) Warrick, J.M., Chan, H.Y.E., Gray-Board, G.L., Chai, Y., Paulson, H.L. and Bonini, N.M. (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nature Genetics 23, 425-428.[ abstract ]

4) Chan, H.Y.E., Harris, S.J. and OKane, C.J. (1998) Identification and characterization of kraken, a putative hydrolytic enzyme in Drosophila melanogaster. Gene 222, 195-201. [ abstract ]

3) Chan, H.Y.E., Zhang, Y., Hoheisel, J. and OKane, C.J. (1998) Identification and characterization of the gene for Drosophila L3 ribosomal protein. Gene 212, 119-125. [ abstract ]

2) Chan, H.Y.E., Zhang, Y. and OKane, C.J. (1997) Identification and characterization of the gene for Drosophila S20 ribosomal protein. Gene 200, 85-89. [ abstract ]

1) Chan, H.Y., Chan, Y.C., Kam, K.M., Shaw, P.C. (1994) Isolation and characterization of restriction endonuclease EclHKI from an Enterobacter cloacae strain. World Journal of Microbiology and Biotechnology 10, 30-32. [ abstract ]