[ back ]

Publication List:

* denotes corresponding author

96) Zhou, P., Chan, B.K.C., Wan, Y.K., Yuen, C.T.L., Choi, G.C.G., Li, X., Cheung, L.W.T., Tan, K., Wong, K.H., H.Y.E. Chan and Wong, A.S.L.* (2020) Three-way combinatorial CRISPR screen for analysing interactions among druggable targets. Cell Rep. 32, 108020 [ abstract ]

95) Lee, L.K., Leong, L.I., Liu, Y., Luo, M., Chan, H.Y.E.* and Choi, C.H.J.* (2020) Preclinical nanomedicines for polyglutamine-based neurodegenerative diseases. Mol. Pharm. (in press) doi: 10.1021/acs.molpharmaceut.0c00506 [ abstract ]

94) Wang, Q., Ren, T., Zhao, J., Wong, C.H., Chan, H.Y.E. and Zuo, Z. (2020) Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations. J. Pharm. Biomed. Anal. 178:112946 [ abstract ]

93) Yu, A.C., Yim, A.K., Chan, A.Y., Yuen, L.Y.P., Au, W.C., Cheng, T.H.T., Lin, X., Li, J.W., Chan, L.W.L., Mok, V.C.T., Chan, T.F.* and Chan, H.Y.E.* (2019) A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases. Front Neurosci. 13:1324.[ abstract ]

92) Chau, D.D., Yung, K.W., Chan, W.W., An, Y., Hao, Y., Chan, H.Y.E., Ngo, J.C. and Lau, K.F. (2019) Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35. FASEB J. 33, 12019-12035. [ abstract ]

91) Lee, J., Bai, Y., Chembazhi, U.V., Peng, S., Yum, K., Luu, L.M., Hagler, L.D. Serrano, J.F., Chan, H.Y.E., Kalsotra, A. and Zimmerman, S.C. (2019) Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1. Proc. Natl. Acad. Sci. USA 116, 8709-8714. [ abstract ]

90) Chen, Z.S. and Chan, H.Y.E. (2019) Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain? Neural Regen. Res. 14, 1148-1151. [ abstract ]

89) Law, C. O.K., Huang, C., Pan, Q., Lee, J., Hao, Q., Chan, T.F., Lo, N.W., Ang, I.L., Koon, A., Ip, M., Chan, H.Y.E. and Lau, T.C.K. (2019) A small RNA transforming multidrug resistance Pseudomonas aeruginosa to drug-susceptibility. Mol. Ther. Nucleic Acids 16, 218-228. [ abstract ]

88) Zhang, Q., An, Y., Chen, Z.S., Koon, A.C., Lau, K.F., Ngo, J.C.* and Chan, H.Y.E.* (2019) A peptidylic inhibitor for neutralizing r(GGGGCC)exp-associated neurodegeneration in C9ORF72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Mol. Ther. Nucleic Acids 16, 172-185. [ abstract ]

87) Kim, M.R., Feng, T., Zhang, Q., Chan, H.Y.E. and Chau, Y. (2019) Co-encapsulation and co-delivery of peptide drugs via polymeric nanoparticles. Polymers 11(2), 288 [ abstract ]

86) Chen, Z.S., Wong, A.K.Y., Cheng, T.C., Koon, A.C. and Chan, H.Y.E.* (2019) FipoQ/FBXO33, a Cullin-1 based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. J. Neurochem. 149, 781-798 (Featured on the cover of the issue)[ abstract ]

85) Hong, H., Koon, A.C., Chen, Z.S., Wei, Y., An, Y., Li, W., Lau, M.H.Y., Lau, K.F., Ngo, J.C.K., Wong, C.H., Au-Yeung, H.Y., Zimmerman, S.C., Chan, H.Y.E.* (2019) AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models. J. Biol. Chem. 294, 2757-2770 (Featured on the cover of the issue) [ abstract ]

84) Lenska-Mieciek, M., Charzewska, A., Krolicki, L., Hoffman-Zacharska, D., Chen, Z.S., Lau, K.F., Chan, H.Y.E., Gambin, T. and Fiszer, U. (2019) Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene. Mov. Disord. 34, 142-144.[ abstract ]

83) Wang, Q., Peng, S., Hu, Y., Wong, C.H., Kwan, K.M., Chan, H.Y.E. and Zuo, Z. (2019) Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration. Eur. J. Pharm. Sci. 127, 240-251.[ abstract ]

82) Yang, M., Zhang, Q., Wang, Q., Sorensen, K.K., Boesen, J.T., Ma, S.Y., Jensen, K.J., Kwan, K.M., Ngo, J.C.K., Chan, H.Y.E. and Zuo, Z. (2018) Brain-targeting delivery of two peptidylic inhibitors for their combination therapy in transgenic polyglutamine disease mice via intranasal administration. Mol. Pharm. 15, 5781-5792. [ abstract ]

81) Koon, A.C., Chen, Z.S., Peng, S.H., Fung, J.M., Zhang, X., Lembke, K.M., Chow, H.K., Frank, C.A., Jiang, L.W., Lau, K.F. and Chan, H.Y.E.* (2018) Drosophila Exo70 is essential for neurite extension and survival under thermal stress. J. Neurosci. 38, 8071-8086.[ abstract ]

80) Chen, Z.S., Li, L., Peng, S., Chen, F.M., Zhang, Q., An, Y., Lin, X., Li, W., Chan, T.F., Lau, K.F., Ngo, J.C., Wong, W.T., Kwan, K.M. and Chan, H.Y.E.* (2018) Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative diseases. EMBO Rep. 19, e45419[ abstract ]

79) Tse, W.S., Siu, A.F.Y., Zhang, Q. and Chan, H.Y.E. (2018) Maternal oxytocin responsiveness improves specificity of positive social memory recall. Psychoneuroendocrinology 98, 148-152.[ abstract ]

78) Li, W., Tam, K.M., Chan, W.W., Koon, A.C., Ngo, J.C., Chan, H.Y.E. and Lau, K.F. (2018) Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. J. Biol. Chem. 293, 7674-7688.[ abstract ]

77) Zhang, Q., Chan, Z.S., An, Y., Liu, H., Hou, Y., Li, W., Lau, K.F., Koon, A.C., Ngo, J.C.K.* and Chan, H.Y.E.* (2018) A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases. RNA 24, 486-498. [ abstract ]

76) Wang, Q., Wong, C.H., Chan, H.Y.E., Lee, W.Y. and Zuo, Z. (2018) Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery. Int. J. Pharm. 539, 50-57. [ abstract ]

75) Tse, W.S., Siu, A.F.Y., Zhang, Q., Chan, H.Y.E. and Wong, T.K.Y. (2017) How does maternal oxytocin influence children’s mental health problem and maternal health problem? Psychiatry Res. 258C, 124-129.[ abstract ]

74) Wang, Q., Zhang, Y., Wong, C.H., Chan, H.Y.E. and Zuo, Z. (2017) Demonstration of Direct Nose-to-Brain Transport of Unbound HIV-1 Replication Inhibitor DB213 Via Intranasal Administration by Pharmacokinetic Modeling. AAPS J. 2017 Dec 27;20(1):23. doi: 10.1208/s12248-017-0179-0 [ abstract ]

73) Qu, Z., Bendena, W.G., Nong, W., Siggens, K.W.,, Noriega, F.G., Kai, Z.P., Zang, Y.Y., Koon, A.C., Chan, H.Y.E., Chan, T.F., Chu, K.H., Lam, H.M., Akam, M., Tobe, S.S. and Hui, J.H. (2017) MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods. Proc Biol Sci. 2017 Dec 20;284(1869). pii: 20171827. doi: 10.1098/rspb.2017.1827. [ abstract ]

72) Zhang, Q., Yang, M., Sorensen, K.K., Madsen, C.S., Boesen, J.T., An, Y., Peng, S.H., Wei, Y., Wang, Q., Jensen, K.J., Zuo, Z., Chan, H.Y.E.* and Ngo, J.C.K.* (2017) A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in polyglutamine diseases. Sci. Rep. 7(1):12077. [ abstract ]

71) Guo, P., Chan, H.Y.E. and Lam, S.L. (2017) Conformational flexibility in the RNA stem-loop structures formed by CAG repeats. FEBS Lett. 591, 1752-1760.[ abstract ]

70) Koon, A.C. and Chan, H.Y.E.* (2017) Drosophila melanogaster as a model organism to study RNA toxicity of repeat expansion-associated neurodegenerative and neuromuscular diseases. Front. Cell. Neurosci. 11:70. doi: 10.3389/fncel.2017.00070 [ abstract ]

69) Li L., Ng, N.K. Koon, A.C., Chan, H.Y.E.* (2017) Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eukaryotic translation elongation factor 1 alpha 1. J. Biol. Chem. 292, 5784-5800. [ abstract ]

68) Yu, A.C., Chan, A.Y., Au, W.C., Shen, Y., Chan, T.F.* and Chan, H.Y.E.* (2016) Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11. Cold Spring Harb. Mol. Case Stud. 2(6):a001248 [ abstract ]

67) Bai, Y., Nyuyen, L., Song, Z., Peng, S.H., Zheng, N., Lee, J., Kapoor, I., Cheng, J., Chan, H.Y.E. and Zimmerman, S.C. (2016) Integrating display and delivery functionality with a cell penetrating peptide mimic as a scaffold for intracellular multivalent multi-targeting. J. Am. Chem. Soc. 138, 9498-9507 [ abstract ]

66) Yang, H., Chen, Z., Zhang, L. Yung, W.Y., Leung K.C., Chan, H.Y.E. and Choi, C.H.J.* (2016) Mechanism for the cellular uptake of targeted gold nanorods of defined aspect ratios. Small 12, 5178-5189 [ abstract ]

65) Luu, L.M., Nyuyen, L., Peng, S., Lee, J., Lee, H.Y., Wong, C.H., Hergenrother, P.J., Chan, H.Y.E.* and Zimmerman, S.C.* (2016) A potent inhibitor of protein sequestration by expanded triplet (CUG) repeats that shows phenotypic improvements in a Drosophila model of myotonic dystrophy. ChemMedChem 11, 1428-1435. [ abstract ]

64) Liao, Q, Chan, A,Y,Y,, Chan, H.Y.E., Mok, V.C.T., Baum, L. (2016) Haplotype analysis of association between Parkinson¡¦s disease and the embryonic lethal, abnormal vision-like 4 (ELAVL4) gene. J. Biochem. Mol. Biol. Post Genomic Era 3, 129-37. [ abstract ]

63) Ko, C.H., Koon, C.M., Yu, S.L., Lee, K.Y., Lau, C.B., Chan, E.H., Wing, Y.K., Fung, K.P. and Leung, P.C. (2016) Hypnotic effects of a novel anti-insomnia formula on drosophila insomnia model. Chin. J. Integr. Med. 22, 335-343. [ abstract ]

62) Wang, Q., Zhang, Y., Qian S., Peng, S., Zhang, Q., Wong, C.H., Chan, H.Y.E. and Zuo, Z. (2016) Pharmacokinetic and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats. J. Pharm. Biomed. Anal. 125, 41-47. [ abstract ]

61) Zhang, Q., Tsoi, H., Peng, S., Li, P.P., Lau, K.F., Rudnicki, D.D., Ngo, J.C. and Chan, H.Y.E.* (2016) Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila. Dis. Model. Mech. 9, 321-34 [ abstract ]

60) Nguyen, L., Luu, L.M., Peng, S., Serrano, J.F., Chan, H.Y.E. and Zimmerman, S.C. (2015) Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy Type 1. J. Am. Chem. Soc. 137, 14180-14189 [ abstract ]

59) Sun, X., Li, P.P., Zhu, S., Cohen, R., Marque, L.O., Ross, C.A., Pulst, S.M., Chan, H.Y.E., Margolis, R.L. and Rudnicki, D.D. (2015) Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65. Sci. Rep. 28;5:12521. [ abstract ]

58) Chow, W.N., Ngo, J.C., Li, W., Chen, Y.W., Tam, K.M., Chan H.Y.E., Miller, C.C. and Lau, K.F. (2015) Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing. Biochem. J. 470, 303-17. [ abstract ]

57) Tsoi H., Li, L., Chan, Z.S., Lau, K.F., Tsui, S.K. and Chan, H.Y.E.* (2014) The SARS-Coronavirus Membrane protein induces apoptosis via interfering PDK1-PKB/Akt signaling. Biochem. J. 464, 439-447.[ abstract ]

56) Chan, H.Y.E.* (2014) RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis. Front. Cell. Neurosci. 8:431. doi: 10.3389/fncel.2014.00431 [ abstract ]

55) Tsoi, H., Yu, A.C., Chen, Z.S., Ng, N.K., Chan, A.Y., Yuen, L.Y., Abrigo, J.M., Tsang, S.Y., Tsui, S.K., Tong, T.M., Lo, I.F., Lam, S.T., Mok, V.C, Wong, L.K., Ngo, C.K., Lau, K.F., Chan, T.F.* and Chan, H.Y.E.* (2014) A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia. J. Med. Genet. 51, 590-595. [ abstract ]

54) Wong, C.H., Nguyen, L., Peh, J., Luu, L.M., Sanchez, J.S., Richardson, S.L., Tuccinardi, T., Tsoi, H., Chan, W.Y., Chan, H.Y.E., Baranger, A.M., Hergenrother, P.J. and Zimmerman, S.C. (2014) Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor. J. Am. Chem. Soc. 136, 6355-61.[ abstract ]

53) Tsoi, H. and Chan, H.Y.E.* (2014) Roles of the nucleolus in the CAG RNA-mediated toxicity. Biochim. Biophys. Acta. 1842, 779-784.[ abstract ]

52) Cheung, H.N., Dunbar, C., Morotz, G.M., Cheng, W.H., Chan, H.Y.E., Miller, C.C. and Lau, K.F. (2014) FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J. 28, 337-349. [ abstract ]

51) Zuo, Y., Peng, C., Liang, Y., Ma, K.Y., Chan, H.Y.E., Huang, Y. and Chen, Z.Y. (2013) Sesamin extends the mean lifespan of fruit flies. Biogerontology 14, 107-119.[ abstract ]

50) Tsoi, H. and Chan, H.Y.E.* (2013) Expression of expanded CAG transcripts triggers nucleolar stress in Huntington¡¦s disease. Cerebellum 12, 310-312. [ abstract ]

49) Ng, C.F., Ko, C.H., Koon, C.M., Xian, J.W., Leung, P.C., Fung, K.P., Chan, H.Y.E. and Lau, C.B. (2013) The aqueous extract of rhizome of Gastrodia elata protected Drosophila and PC12 cells against beta-amyloid-induced neurotoxicity. Evid. Based Complement Alternat. Med. 2013:516741.[ abstract ]

48) Tsoi, H., Lau, C.K., Tsang, S.Y., Lau, K.F. and Chan, H.Y.E.* (2012) CAG expansion induces nucleolar stress in polyglutamine diseases. Proc. Natl. Acad. Sci. USA.109, 13428-13433. [ abstract ]

47) Lu, J.H., Tan, J.Q., Durairajan, S.S., Liu, L.F., Zhang, Z.H., Ma, L., Shen, H.M., Chan, H.Y.E.* and Li, M.* (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8, 98-108.[ abstract ]

46) Peng, C., Zuo, Y., Kwan, K.M., Liang, Y., Ma, K.Y., Chan, H.Y.E., Huang, Y., Yu, H. and Chen, Z.Y. (2012) Blueberry extract prolongs lifespan of Drosophila melanogaster. Exp. Gerontol. 47, 170-178.[ abstract ]

45) Hao, Y., Chai, K.H., McLoughlin, D.M., Chan, H.Y.E. and Lau, K.F. (2012) Promoter characterization and genomic organization of the human X11£] gene APBA2. Neuroreport 23, 146-151.[ abstract ]

44) Chai, K.H., McLoughlin, D.M., Chan, T.F., Chan, H.Y.E. and Lau, K.F. (2012) Genomic organization and promoter cloning of the human X11a gene APBA1. DNA Cell Biol. 31, 651-659.[ abstract ]

43) Chow, W.N., Luk, H.W., Chan, H.Y.E. and Lau, K.F. (2012) Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65. Biochem. J. 443, 681-689.[ abstract ]

42) Tsoi, H., Lau, T.C.K., Lau, K.F. and Chan, H.Y.E.* (2011) Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Hum. Mol. Genet. 20, 3787-3797.[ abstract ]

41) Chan, W.M., Tsoi, H., Wu, C.C., Wong, C.H., Cheng, T.C., Li, H.Y., Lau, K.F., Shaw, P.C., Perrimon, N. and Chan, H.Y.E.* (2011) Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Hum. Mol. Genet. 20, 1738-1750.[ abstract ]

40) Hao, Y., Perkinton, M.S., Chan, W.W., Chan, H.Y.E., Miller, C.C. and Lau, K.F. (2011) GULP1 is a novel APP-interacting protein that alters APP processing. Biochem. J. 436, 631-639.[ abstract ]

39) Peng, C., Chan, H.Y.E., Huang, Y., Yu, H. and Chen, Z.Y. (2011) Apple polyphenols extend lifespan of Drosophila melanogaster. J. Agri. Food Chem. 59, 2097-2106.[ abstract ]

38) Cheng, T.C., Chen, Y.W., Wong, K.B., Ngai, S.M. and Chan, H.Y.E.* (2010) Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis. Acta. Cryst. F 66, 546-548.[ abstract ]

37) Lee, F.K.M., Wong, A.K.Y., Lee, Y.W., Wan, O.W., Chan, H.Y.E.*, and Chung, K.K.K.* (2009) The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson s disease. J. Neurochem. 110, 208-219.[ abstract ]

36) Peng, C., Chan, H.Y.E., Li, Y.M., Huang, Y. and Chen, Z.Y. (2009) Black tea theaflavins extend the lifespan of fruit flies. Exp. Gerontol. 44, 773-783.[ abstract ]

35) Lam, S.K., Cai, Y., Tse, Y.C., Wang, J., Law, A.H.Y., Pimpl, P., Chan, H.Y.E., Xia, J., and Jiang, L.W. (2009) The BFA-induced compartments from Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. Plant J. 60, 865-881.[ abstract ]

34) Chan, C.M., Tsoi, H., Chan, W.M., Zhai, S., Wong, C.O., Yao, X., Chan, W.Y., Tsui, S.K.W., and Chan, H.Y.E.* (2009) The ion channel activity of the SARS-Coronavirus 3a protein is linked to its pro-apoptotic function. Int. J. Biochem. & Cell Biol. 41, 2232-2239[ abstract ]

33) Lau, K.F., Chan, W.M., Perkinton, M.S., Chang, R.C.C., Chan, H.Y.E., McLoughlin, D.M., and Miller, C.C.J. (2008) Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein dependent transcription. J. Biol. Chem. 283, 34728-34737. [ abstract ]

32) Mugat, B., Parmentier, M.L., Bonneaud, N., Chan, H.Y.E., and Maschat, F. (2008) Protective role of Engrailed in a Drosophila model of Huntington"s disease. Hum. Mol. Genet. 17, 3601-3616. [ abstract ]

31) Lam, W., Chan, W.M., Lo, T.W., Wong, A.K.Y., Wu, C.C. and Chan, H.Y.E.* (2008) Human receptor for activated protein kinase C1 associates with polyglutamine aggregates and modulates polyglutamine toxicity. Biochem. Biophys. Res. Comm. 377, 714-719. [ abstract ]

30) Wong, J.H., Chan, H.Y.E. and Ng, T.B. (2008) A mannose/glucose-specific lectin from Chinese evergreen chinkapin (Castanopsis chinensis). Biochimica et Biophysica Acta. 1780, 1017-1022.[ abstract ]

29) Wong, A.K.Y., Chan, H.Y.E.* and Chan, W.M. (2008) Recent developments in targeted transgene expression systems. Fly 2, 169-171.[ abstract ]

28) Chen, F., Chan, H.Y.E., Wong, K.L., Wang, J., Yu, M.T., But, P.P. and Shaw, P.C. (2008) Authentication of Saussurea lappa, an Endangered Medicinal Material, by ITS DNA and 5S rRNA Sequencing. Planta Medica 74, 889-892.[ abstract ]

27) Li, Y.M., Chan, H.Y.E., Huang, Y. and Chen, Z.Y. (2008) Broccoli improves the survival and up-regulates endogenous antioxidant enzymes in Drosophila melanogaster challenged with reactive oxygen species. Journal of the Science of Food and Agriculture. 88, 499-506. [ abstract ]

26) Li, Y.M., Chan, H.Y.E., Yao, X.Q., Huang, Y. and Chen, Z.Y. (2008) Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster. Journal of Nutritional Biochemistry.19, 376-383. [ abstract ]

25) Wong, S.L.A., Chan, W.M. and Chan, H.Y.E.* (2008) SDS-insoluble polyglutamine oligomers are involved in neuronal degeneration. FASEB J. 22, 3348-3357. [ abstract ]

24) Chan, W.M., Shaw, P.C. and Chan, H.Y.E.* (2007) A green fluorescent protein-based reporter for protein import studies in Drosophila cells. Fly 1, 340-342. [ abstract ]

23) Li, Y.M., Chan, H.Y.E., Huang, Y. and Chen Z.Y. (2007) Green Tea Catechins Up-Regulate Superoxide Dismutase and Catalase in Fruit Flies. Mol. Nutr. & Food Res. 51, 546-554. [ abstract ]

22) Huen, N.Y.M., Wong, S.L.A. and Chan, H.Y.E.* (2007) Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias. The Cerebellum. (Invited review) 6, 111-117. [ abstract ]

21) Chan, C.M., Ma, C.W., Chan, W.Y. and Chan, H.Y.E.* (2007) The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway. Arch. Biochem. Biophys. 459, 197-207. (Featured on the cover of the issue) [ abstract ]

20) Chau, K.W., Chan, W.Y., Shaw, P.C., Chan, H.Y.E.* (2006) Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. Biochem Biophys Res Commun.346(1):150-9.[ abstract ]

19) Yiu, C.P.B., Beavil, R.L. and Chan, H.Y.E.* (2006) Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble. Biochem. Biophy. Res. Comm. 343, 311-318. [ abstract ]

18) Wong, S.L.A., Chen, Y.W., Chan, C.M. , Chan, C.S.M., Chan, P.K.S., Chui, Y.L., Fung, K.P., Waye, M.M.Y., Tsui, S.K.W. and Chan, H.Y.E.* (2005) In vivo functional characterization of the SARS Coronavirus 3a protein in Drosophila. Biochem. Biophy. Res. Comm. 337, 720-729. (Featured on the cover of the issue)[ abstract ]

17) Huen, N.Y.M. and Chan, H.Y.E.* (2005) Dynamic regulation of molecular chaperone gene expression in polyglutamine disease. Biochem. Biophy. Res. Comm. 334, 1074-1084.[ abstract ]

16) Law, P.T.W., Wong, C.H., Au, T.C.C., Chuck, C.P., Kong, S.K., Chan, P.K.S.,To, K.F., Lo, A.W.I., Chan, J.Y.W., Suen, Y.K., Chan, H.Y.E., Fung, K.P., Waye, M.M.Y., Sung, J.J.Y., Lo, Y.M.D., Tsui, S.K.W. (2005) The 3a protein of severe acute respiratory syndrome-coronavirus induces apoptosis in Vero E6 cells. J. Gen. Virol. 86, 1921-1930. [ abstract ]

15) Kusano, A., Staber, C., Chan, H.Y.E. and Ganetzky, B. (2003) Closing the (Ran)GAP on Segregation distortion in Drosophila. BioEssays 25, 108-115. (Featured on the cover of the issue)[ abstract ]

14) Chan, H.Y.E. and Bonini, N.M. (2003) Drosophila models of polyglutamine diseases. In: Methods in Molecular Biology; v. 217- Neurogenetics: Methods and protocols, (ed Potter N). Humana Press, Totowa, NJ, USA, pp. 241-251.[ abstract ]

13) Chan, H.Y.E.* (2002) Fly-ing from genes to drugs. Trends Mol. Med. 8(3), 99-101.[ abstract ]

12) Auluck, P.K., Chan, H.Y.E., Trojanowski, J.Q., Lee, V.M.Y. and Bonini, N.M. (2002) Chaperone suppression of a-synuclein toxicity in a Drosophila model for Parkinsons disease. Science 295, 865-868.10.1126/science.1067389[ abstract ]

11) Chan, H.Y.E.*, Tung, C.K.C. And Okane, C.J. (2002) Rev::GFP transgenic lines for the studies of nucleocytoplasmic transport in Drosophila. Genesis 34, 139-141.[ abstract ]

10) Chan, H.Y.E., Warrick, J.M., Andriola, I., Merry, D.E. and Bonini, N.M. (2002) Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Hum. Mol. Genet. 11, 2895-2904.[ abstract ]

9) Chan, H.Y.E., Brogna, S. and OKane, C.J. (2001) Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Mol. Biol. Cell 12, 1409-1419.[ abstract ]

8) Chan, H.Y.E., Warrick, J.M., Gray-Board, G.L., Paulson, H.L. and Bonini, N.M. (2000) Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy, and modulation of protein solubility in Drosophila. Hum. Mol. Genet. 9, 2811-2820. (Featured on the cover of the issue)[ abstract ]

7) Chan, H.Y.E. and Bonini, N.M. (2000) Drosophila models of human neurodegenerative disease. Cell Death and Differentiation 7, 1075-1080.[ abstract ]

6) Collier, S., Chan, H.Y.E., Toda, T., MacKimmie, C., Johnson, G., Adler, P., OKane, C. and Ashburner, M. (2000) The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of Schizosaccharomyces crm1. Genetics 155, 1799-1807.[ abstract ]

5) Warrick, J.M., Chan, H.Y.E., Gray-Board, G.L., Chai, Y., Paulson, H.L. and Bonini, N.M. (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nature Genetics 23, 425-428.[ abstract ]

4) Chan, H.Y.E., Harris, S.J. and OKane, C.J. (1998) Identification and characterization of kraken, a putative hydrolytic enzyme in Drosophila melanogaster. Gene 222, 195-201. [ abstract ]

3) Chan, H.Y.E., Zhang, Y., Hoheisel, J. and OKane, C.J. (1998) Identification and characterization of the gene for Drosophila L3 ribosomal protein. Gene 212, 119-125. [ abstract ]

2) Chan, H.Y.E., Zhang, Y. and OKane, C.J. (1997) Identification and characterization of the gene for Drosophila S20 ribosomal protein. Gene 200, 85-89. [ abstract ]

1) Chan, H.Y., Chan, Y.C., Kam, K.M., Shaw, P.C. (1994) Isolation and characterization of restriction endonuclease EclHKI from an Enterobacter cloacae strain. World Journal of Microbiology and Biotechnology 10, 30-32. [ abstract ]